Participants who scored higher on the 2-item Diabetes Distress Scale, lower on the Diabetes Empowerment Scale, and had greater insulin use at enrollment were more likely to report feeling stressed on at least 1 blood glucose reading (2-item Diabetes Distress Scale score: 2.61.25 vs 2.091.11, respectively, P<.001; Diabetes Empowerment Scale score: 3.80.79 vs 3.90.79, respectively, P<.001; insulin: 35.1% vs 28.9%, respectively, P<.001). Here, INS is linked to diabetes mellitus.