As suggested recently, AP-1 co-localization with other transcription factors in enhancer regions depends on cell lineage (Vierbuchen et al., 2017), such as AP-1 and TEAD in MEFs (Vierbuchen et al., 2017) and breast cancer cells (Zanconato et al., 2015) and AP-1 and ETS family members in oesophageal adenocarcinoma (Britton et al., 2017). The gene discussed is FOS; the disease is breast carcinoma.