SMARCA4 and cancer: Unlike most other adult cancers with BRG1 mutations, such as non-small cell lung cancer (NSCLC), SCCOHT tumors have a simple genetic background and rarely have secondary mutations in other cancer driving genes (Karnezis et al., 2016; Clarke et al., 2016; Ramos et al., 2014a; Ramos et al., 2014b; Kupryjańczyk et al., 2013; Witkowski et al., 2014; Jelinic et al., 2014; Lin et al., 2017).