NLRP3 and infection: In macrophages, STm infection can be detected by caspase‐11 (human caspase‐4) and sensed by NLRP3, which recruits the adaptor ASC (apoptosis‐associated speck‐like protein containing a CARD) that oligomerises into “specks” within which caspase‐1 is activated (Broz et al., 2012; Casson et al., 2015; Fisch, Bando, et al., 2019).