Supporting this idea, conditional activation of the Notch pathway by N2ICD (the active form of Notch2) overexpression significantly suppressed the progression of tumors in Trp53, Rb1 and p130 (also known as Nolc1) triple-knockout mice, indicating a negative role of Notch signaling in SCLC development (George et al., 2015). The gene discussed is NOTCH2; the disease is small cell lung carcinoma.