NLRP3 and COVID-19: Hypoxemia, one of the most important cellular changes in the context of COVID-19, is one of the potent DAMP signals for NLRP3 activation.21Thus, the inflammation, coagulation, and hypoxemia, as evident in our pathway enrichment analysis, in a highly interrelated fashion could be postulated in enhancing thrombotic condition and disease severity in COVID-19 patients.