Although VDR‐null mice usually do not spontaneously develop more cancers, they are more likely to develop a range of malignancies, such as breast,(129) colon,(130) and skin(131, 132) cancer, when exposed to oncogenes, loss of antioncogenes, or exposure to carcinogens or UVB light.(133, 134) This is in line with the “cancer hypothesis,” where the risk of cancer development is associated with multiple events. Here, VDR is linked to cancer.