Ca 125 is the primary biomarker used now; however, it is only used for follow-up rather than diagnosis. It is not sensitive nor specific enough to be used in screening. A recent study exploring this biomarker's diagnostic value with infertility and finding other valuable biomarkers hypothesized that the combined use of IL6 and IL8 with CA125 has a higher predictability value than CA125 alone [27]. The gene discussed is IL6; the disease is Infertility.