CAR, chimeric antigen receptor; CLL, chronic lymphocytic leukemia; CR, complete response rate; CRS, cytokine release syndrome; DLBCL, diffuse large B-cell lymphoma; HLH, hemophagocytic lymphohistiocytosis; ORR, objective response rate; PFS, progression-free survival; PMBCL, primary mediastinal B-cell lymphoma; TFL, transformed follicular lymphoma. The gene discussed is ZC3H12D; the disease is B-cell chronic lymphocytic leukemia.