According to GO and KEGG analysis, biological processes, cellular component, molecular function, and pathway terms were differentially enriched between genes positively and negatively correlated with PLK1 in CESC and cervicla adenocarcinoma, which implied that genes positively and negatively correlated with PLK1 played various functions in development of CESC and cervical adenocarcinoma. The gene discussed is PLK1; the disease is cervical adenocarcinoma.