In addition to the processed antigen at major histocompatibility complex I (MHC-I), immune cells could also target the viral envelop protein HN on the surface of the rAF-IL12-infected tumor hence, could prevent the cancer from escaping the immune destruction through the downregulation of MHC-I expression as shown in previous studies (Zakay-Rones, Tayeb & Panet, 2015; Schirrmacher, 2017; Al-shamery et al., 2011; Pan et al., 2013). Here, ERVW-1 is linked to neoplasm.