The importance of granzyme B expression is justified by previous study which demonstrated that low expression of granzyme B was associated with early signs of metastasis in CRC while higher tumor infiltration with CTL and granzyme B improved all-cause and cancer specific survival of CRC patients, irrespective of stage (Prizment et al., 2017; Salama et al., 2011). This evidence concerns the gene GZMB and neoplasm.