CASP8 and cancer: Previous studies have shown that the loss of Bax and caspase-8 expression in tumor cells are not only causing evasion of apoptosis but are also correlated with resistance to drug-induced apoptosis treatment as well as giving shorter survival time in cancer patients (Paul-Samojedny et al., 2005; Pryczynicz et al., 2014; Sträter et al., 2010).