IFNG and neoplasm: Interestingly, despite invoking the same immune response as the parental AF2240-i, the IL-12 expression of rAF-IL12-infected tumor mass could enhance its in vivo oncolytic activity and edging out the AF2240-i as rAF-IL12 treatment was the only group that managed to elicit the expression of IL-12 and IFN-γ cytokines in the nude mice.