It was reported that caspase 8 and Fas-associated protein with death domain-like apoptosis regulator (CFLAR) could directly target ASK1 and interrupt its N-terminus-mediated dimerization, thereby blocking signaling involving ASK1 and JNK, subsequently improving hepatic lipid accumulation and IR by regulating PPARα and IRS1, and improving inflammation by regulating c-Jun and c-Fos, which therefore regulates NASH in mice and nonhuman primates [16]. The gene discussed is MAP3K5; the disease is metabolic dysfunction-associated steatohepatitis.