CFLAR is the key regulator of the metabolic disorders associated with NASH, which can block the activation of apoptosis signal regulating kinase 1 (ASK1) by destroying ASK1 N-terminal mediated dimerization and affecting the phosphorylation of JNK and therefore alleviate NASH in mice and nonhuman primates [16]. This evidence concerns the gene MAP3K5 and metabolic dysfunction-associated steatohepatitis.