TNF and ulcer disease: It is therefore possible that the secondary metabolites present in this plant exhibited a healing effect on gastric lesions through an anti-inflammatory action, by inhibiting the activities of COX and 5-LOX and by reducing the TNF-α, IL-1β, IL-6, and PGE2 secretions, thus leading to a reduction in mucosal cell proliferation with the consequence of stopping tissue destruction and reestablishing ulcers.