CASP8 and neoplasm: To examine whether BmooLAAO-I induced apoptosis via the intrinsic or extrinsicpathway activation, we analyzed the expression levels of caspases 3, 8, and 9.The toxin lowered expression of pro-caspases 3, 8, and 9 in all tumor cell lines(Fig. 4) and increased the levels ofcleaved caspase 8 in K562-R cells (Fig. 4D)and HL-60.Bcr-Abl cells (Fig. 4B).