IL4I1 and melanoma: Inagreement with our findings, LAAO isolated from Bothrops alternatusand Bothrops jararacussu snake venoms induce ROS overproduction inmany tumor cell types, including hepatocarcinoma, leukemia T, breast cancer,adenocarcinoma, and melanoma; however, the enhanced ROS levels are associated withanti-tumor effects due their contribution to cell death and DNA damage [43,44].