Tumor-infiltrating CD8+ T cells also showed decreased abundance of TOX, programmed cell death protein-1 (PD-1), T cell immunoglobulin, mucin domain-3 (TIM-3), and killer cell lectin-like receptor subfamily G member 1 (KLRG1), indicating the cells remained functional effector cells (Fig. 5f–i and Supplementary Fig. 2). This evidence concerns the gene CD8A and neoplasm.