MAP3K1 mutation rates were lower in Asians irrespective of ER status (Fig. 2c; p = 0.02 and p = 0.03 in ER+ and ER–, respectively), whereas CDH1 mutation rates were lower in ER+ Asian tumours (p = 0.03), although there was no difference in CDH1 mutation rates after accounting for histological subtype (Supplementary Fig. 10). The gene discussed is MAP3K1; the disease is neoplasm.