TNS1 and breast neoplasm: However, Kaplan–Meier survival analysis indicates that the expression of Tns1 is increased in grade 3 breast tumors38 supporting our findings of a positive role of Tns1 in breast tumor progression mediated by MaTAR25. Although Tns1 is the top target of MaTAR25 with the highest statistical significance we cannot rule out the possibility that MaTAR25 also regulates other genes as well given the additional candidates identified in our ChIRP-seq analysis.