TNF and inflammatory bowel disease: Mesalazine and cortico-steroids are the mainstays of treatment of de novo IBD even in transplant patients [26, 28, 33], although recent reports suggested the use of anti-TNFα antibodies for patients refractory to standard therapy [31, 33]: however, approximately 20% of patients are refractory to therapy and ultimately need surgical treatment with colectomy [31, 33].