CB electrical modulation have also been tested for metabolic diseases, with Sacramento et al. showing that kilohertz frequency alternating current (KHFAC) modulation, and therefore electrical blocking applied continuously to the CSN was able to restore after 1 week, and maintain during 9 weeks insulin sensitivity and glucose tolerance in an early type 2 diabetes animal model (Sacramento et al. 2018). This evidence concerns the gene INS and type 2 diabetes mellitus.