In the present study, we have aimed to systematically assess the mutational spectrum of the RNase H2 subunit genes RNASEH2A, RNASEH2B and RNASEH2C in a relatively large case-control series of 602 German patients with EOC and 940 healthy German females to elucidate their possible contribution to ovarian cancer risk and prognosis. The gene discussed is RNASEH2C; the disease is ovarian cancer.