It was observed that Ginkgo biloba extract or its components given to animals in a model of ischemia-induced brain injury improved neurologic function and reduced ischemia/reperfusion-induced injury relative to sham-treated control animals in a process whereby the Ginkgo biloba treatment significantly increased neuronal HO-1 expression, resulting in neuroprotection in the brain [102,103]. This evidence concerns the gene HMOX1 and ischemia.