IGFBP7 and neoplasm: In addition, anti-IGFBP7 Nbs were used to functionalize both Gadolinium (Gd)-coated lipid nanoparticles and superparamagnetic iron oxide nanoparticles for the MRI imaging of tumor angiogenesis [149,150]: of note, bio-conjugation of those nanoparticles with Cy5.5 dye allowed the development of a bimodal optical-MRI in vivo imaging contrast agent.