99mTc-conjugated anti-MMR Nbs have been developed and used for the visualization of mouse model of mammary adenocarcinoma and Lewis lung carcinoma by SPECT/CT [97]: anti-MMR Nbs selectively identified MMR+ TAMs infiltrating hypoxic regions, with a high tumor-to-background ratio. The gene discussed is MRC1; the disease is Carcinoma, Lewis Lung.