ANXA1 and pachyonychia congenita: In the present paper, based on the fact that (i) the extracellular microvesicles have an important role in PC progression, (ii) ANXA1 is involved in the exosomes biogenesis and/or effects, and (iii) the extracellular counterpart of this protein is able to trigger cell motility [5,6,14,54,55], we decided to investigate the in vitro mechanism of action of ANXA1/EVs on fibroblasts and endothelial cells as recipient stromal cells.