In this study, we have observed that CKD patients with severe CAD disease showed a higher systolic blood pressure, a higher count of circulating proinflammatory CD14++CD16+ monocytes, and higher susceptibility to acute kidney injury (CSA-AKI) and death after CABG surgery than patients with eGFR > 60 mL/min, indicating that pathological pathways in atherogenesis progression might differ between patients with intact or impaired renal function. This evidence concerns the gene CD14 and coronary artery disorder.