Interestingly, the cohousing of CASP1 KO, ASC KO, NLRP3 KO, and IL-18 KO mice with WT animals before induction of NASH with an MCD diet resulted in significant exacerbation of NASH in the WT cage mates, suggesting that the development of NASH could be transmissible via gut microbiota [134]. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.