TP53 and hepatocellular carcinoma: Figure 4A gives an overview of the detected genetic alterations in patients assorted to their best response with PR, SD, or PD. First, we compared the frequency of common oncogenic driver mutations in HCC to published data of the Cancer Genome Atlas (TCGA), and second, we explored possible associations with response or resistance to ICI treatment [22]. In line with the TCGA cohort, mutations in the tumor suppressor gene TP53 (in 40% of patients), the WNT-pathway oncogene CTNNB1 (27%), and amplifications in the oncogene MYC (27%) were among the most often altered genes (Figure 4A).