IL6 and Myocardial fibrosis: Moreover, excessive myocardial fibrosis, at the moment of AVR surgery, has been associated with impaired recovery of the left ventricle (LV) systolic function, poor long-term outcomes after the treatment [4,5], and correlated with levels of systemic and tissue inflammation markers, such as interleukin-6 (Il-6) and C-reactive protein [6].