RUNX1 and myeloid leukemia: The RUNX1 gene is a Runt-related transcription factor, also known as AML1 (acute myelogenous leukemia 1), that regulates the expression of several important hematopoietic regulator genes [50,51,52,53,54], including genes regulating B-cell maturation [55], granulocyte differentiation, and megakaryocyte maturation [56].