BCL-2 was identified because it is frequently amplified in non-Hodgkin’s B-cell lymphomas via t(14;18) chromosomal translocations that place BCL-2 at 18q21 under the control of potent enhancers of the immunoglobulin heavy-chain locus at 14q32 (reviewed in [145]). The gene discussed is BCL2; the disease is B-cell non-Hodgkin lymphoma.