The latest research has found the existence of interactions between famine and some genes in the occurrence of type 2 diabetes, which means that some variants may influence susceptibility of type 2 diabetes amongst the population experiencing famine or malnutrition in early life, such as SIRT1, PPAR-γ2 Pro12Ala, IGF2BP2, etc. [14,15,16]. Here, SIRT1 is linked to type 2 diabetes mellitus.