Besides inhibiting the BACE-1 activity, fucofuroeckol-B exhibited neuroprotective effects against β-amyloid toxicity by reducing the BACE-1-catalyzed cleavage of APP and Aβ generation in a transgenic human neuroblastoma cell line (SH-SY5Y-APP695swe) [61]. Here, BACE1 is linked to neuroblastoma.