Manandhar et al. [51] demonstrated, for the first time, the potent anti-tyrosinase potential of an octamer of phloroglucinol (974-A), as well as its capacity to reduce the cellular melanin content and to downregulate the expression of melanogenic enzymes (tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2) in an α-MSH-induced B16F10 melanoma cells [51]. This evidence concerns the gene TYR and melanoma.