BID and Alzheimer disease: In the middle temporal gyrus, it was found that JNK3 (MAPK10), Bcl-2 family members (Bid, BAK1), and multiple caspases (CASP8, CASP3, CASP7) for example, were also hypomethylated in patients with AD, suggesting an upregulation of apoptotic pathways in AD neurons [94].