TIGIT and neoplasm: On CD8+ T cells, we observed higher levels of LAG3, TIM3, and TIGIT compared to PD1 expression (p = 0.0195, p = 0.0547, and p = 0.0039, respectively, Wilcoxon matched pairs signed rank test) (Figure S6), indicating these immune checkpoints to be potential targets for reinvigorating the cytotoxic and possibly tumor-specific T cells.