A heatmap illustrating the Log2 fold change of the expression of selected genes from primary to recurrent tumor confirmed the pattern that an increase in T cell gene expression is associated with an increase in IFNG gene expression and gene expression of immunosuppressive molecules such as CD274 (PDL1), IDO1, and TGFB1—indicative of adaptive immune resistance (Figure S5A). The gene discussed is IDO1; the disease is neoplasm.