RHOA and ischemia reperfusion injury: In animal model of ischemia-reperfusion injury, inhibitors of RhoA/ROCK signaling pathways demonstrate a cardioprotective effect, which is realized through the activation of MAPK and NFkB signaling pathways and a reduction in Bcl-2 levels, leading to a decrease in the apoptotic activity of cells [18,19,20,21,22].