The recruitment of the monocytes to the tumor and their differentiation into TAMs occurs in response to the cytokines and chemokines, such as the high mobility group box protein 1 (HMGB1) alarmin, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CXCL12, VEGF, PDGF, and IL-10, produced by the cells present in the tumor [8,23]. This evidence concerns the gene HMGB1 and neoplasm.