On the application of 10% LPDS, a significant decrease of LMNB1 gene expression was detected for PXE fibroblasts compared to NHDF (control: 0.66 ± 0.04, PXE: 0.27 ± 0.03; p ≤ 0.001). The gene discussed is LMNB1; the disease is pseudoxanthoma elasticum (inherited or acquired).