Various other examples include: miR-10b, a metastasis-associated miRNA, which targets MICB transcripts in breast cancer cell lines [136]; miR-20a targets MICA and MICB transcripts, and also inhibits the MAPK/ERK pathway to downregulate ULBP2 in breast cancer [137]; miR-34a and miR-34c downregulate ULBP2 [38]; miR-93, miR-20a and miR-106b reduced expression of MICA, MICB, ULBP2 and ULBP3 in glioma cells [138]; and miR-889 which targets MICB transcripts in hepatocellular carcinoma cells [139]. The gene discussed is MICB; the disease is central nervous system cancer.