A further link between DNA damage in cancer cells and NKG2DL expression was later made with the observation that doxycyclin-inducible wild type (but not a DNA-binding mutant variant) p53 mediated ULBP1 and ULBP2 surface upregulation via increased levels of mRNA transcription in p53-null human non-small cell lung cancer cells [35]. The gene discussed is TP53; the disease is cancer.