The protection provided by either intratumoural BO-112 or poly I:C was lost in Batf3−/− mice, which lack conventional DC-1 cells (cDC1), a population with a heightened propensity for cross-priming CD8+ T cells, that was shown to be the major TLR3-positive DC population in the tumour tissue in wild-type animals [34,119,120]. The gene discussed is CD8A; the disease is neoplasm.