ACO2 and posterior cortical atrophy: Several studies have demonstrated that FABP5 depletion leads to the downregulation of lipid metabolism-related genes, such as hormone-sensitive lipase (HSL), monoacylglycerol lipase (MAGL), acyl-CoA synthetase long chain family member 1 (ACSL1), ATP synthase subunit beta (ATP5B), long-chain 3-hydroxy-CoA dehydrogenase (LCHAD), aconitase 2 (ACO2), fumarate hydratase (FH) and mitofusion 2 (MFN2) in PCa cells, suggesting a role for FABP5 in lipid synthesis and metabolism [76,93].