Positron emission tomography (PET) using different radiopharmaceuticals (including small molecules [18F]F-FDG, [11C]C-/[18F]F-choline, [11C]C-acetate, [18F]F-FACBC, and anti-PSMA monoclonal antibodies and small molecule ligands) for imaging of PC in combination with anatomical modalities has been found useful in the detection of biochemical relapse, recurrence, and extent of PC lesions [6,7,8]. This evidence concerns the gene FOLH1 and pachyonychia congenita.