PINK1/PARKIN: The most well studied pathway of mitophagy involves the mitochondrial serine/threonine PTEN-induced kinase 1 (PINK1) and the cytosolic E3-ligase PARKIN, two proteins found to be mutated in familial forms of early onset Parkinson’s disease [4,5]. The gene discussed is PRKN; the disease is Parkinson disease.