Previously, BS-181 was reported to induce G1-arrest and apoptosis, resulting from the down-regulation of G1 cyclin (cyclin D1) and anti-apoptotic proteins (MCL-1 and XIAP) in breast cancer cells [21] and down-regulation of cyclin D1 and XIAP in gastric cancer cells [22]. This evidence concerns the gene CCND1 and breast carcinoma.