TP53 and myeloid leukemia: Previously, the advantage of BCL-2 overexpression was reported in dissecting the correlation between p53-mediated G1-arrest and p53-mediated apoptosis in murine M1 myeloid leukemia cells, in which p53-mediated G1-arrest was not detected unless the simultaneous induction of p53-mediated apoptosis was delayed by BCL-2 overexpression [39].