TNFSF10 and neoplasm: Consistent with previous studies showing that TRAIL induces apoptosis selectively in malignant tumor cells but not in normal cells [41,42], the synergistic effect of rTRAIL (1‒4 ng/mL) on BS-181 cytotoxicity was not detected in either unstimulated or PHA-stimulated normal T cells, but was apparently detected in all tested malignant cells with the highest efficacy in Jurkat cells.