Moreover, CAAs have been demonstrated to be involved in tumor progression, metastasis and therapy resistance by secretion of adipokines, such as leptin and a series of inflammatory chemokines and interleukins [51,53], including tumor necrosis factor (TNF) α, Interleukin (IL)1β, IL6, IL8 and vascular endothelial growth factor (VEGF) which are well known for their effects in promoting tumorigenesis [54,55,56,57]. This evidence concerns the gene LEP and neoplasm.