Here, we will review the role of ligand-activated PPARγ on the epithelial/stromal cells (cellular part) and extracellular matrix (ECM) components/extracellular vesicles (non-cellular part) of the breast cancer microenvironment, highlighting its potential as a novel therapeutic strategy targeting directly cancer cells and/or indirectly disrupting cellular interaction within TME which sustains breast cancer progression. Here, PPARG is linked to cancer.