ERBB2 and breast carcinoma: Interestingly, only cytoplasmic receptor had a strong correlation with poor survival and was associated with high-risk markers of breast cancer such as HER2, the cancer cell marker CD133 and N-cadherin, a well-known indicator for epithelial-to mesenchymal transition (EMT), while nuclear PPARγ expression was negatively correlated with tumor grade as well as with HER2 and N-cadherin expression [42].