Indeed, their work showed that sCD146 exerts autocrine effects on cancer cells to induce the expression of mesenchymal markers such as vimentin, N-cadherin, and the transcription factors Snail and Slug, thus inducing epithelial to mesenchymal transition (EMT) beside its effect on activating cancer stem cell markers that enhance cancer metastatic potential [25]. This evidence concerns the gene CDH2 and cancer.