To be highlighted, new potential prognostic biomarkers of MFS patients can also be explored using Cox regression analysis data constructing OSmfs, such as LYPLA1, DBF4B, MMP13, PLK1, TMEM158, WNT5B and RUNX2, they were here detected to be potential biomarkers to evaluate poor prognosis for MFS patients. Here, RUNX2 is linked to Marfan syndrome.