FTL and neuroferritinopathy: Moreover, it has been observed in vitro that in aging lens epithelial cells, steady degradation of H-chain ferritin contributes to the maintenance of a constant level of this subunit, while the slower turnover of the L chain can result in accumulation of FtL-enriched ferritin associated with cytoplasmic inclusion bodies [33], similar to those observed in neurons differentiated from neuroferritinopathy patient-derived iPSCs [34].