In the current study, metastatic liver tumors had only a few intratumoral CD8+ T cell, and no Treg and CD20+ B cell infiltrations, which indicates the TIME of metastatic liver tumors is close to “immunological ignorance” type (TIL−, PD-L1−), an immunological state in which adaptive immunity is unable to recognize or respond to tumor cells [6,44]. Here, CD8A is linked to neoplasm.