Yet, important factors that exacerbate or lead to LUTS seems to be metabolic syndrome, chronic inflammation, atherosclerosis-induced pelvic ischemia, impaired nitric-oxide synthase pathway in the endothelium, natriuretic peptides imbalance, concomitant conditions (e.g., diabetes, renal failure, obesity, dyslipidemia), and different medications commonly used by cardiologists (e.g., diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers) [7,12,13]. The gene discussed is ACE; the disease is metabolic syndrome.