CASP3 and infection: After DENV infection, we found that the cleaved caspase-3 was increased (Figure 2B), as were cell death rates, within 24 to 72 h post-infection (24 h post-infection: 6.78 ± 0.172% versus 10.74 ± 0.25%, about 1.58-fold change, p < 0.001; 48 h post-infection: 19.81 ± 1.94% versus 33.97± 1.42%, about 1.17-fold change, p < 0.001; 72 h post-infection: 64.79 ± 0.85% versus 74.07 ± 0.91%, about 1.14-fold change, p < 0.001) in Beclin-1 knockdown cells compared with control cells.