The evidence for a detrimental role has accumulated over the past decade and includes 1) reduced atherosclerosis upon ablation of the Adamts7 gene in mice (table 2); 2) GWAS that show an association of ADAMTS7 SNPs with CAD and 3) immunohistochemical detection of ADAMTS-7 in human atherosclerotic plaques. This evidence concerns the gene ADAMTS7 and coronary artery disorder.