In corroboration of these findings, Cul7flox/floxMyh6-Mer-Cre-MerTg(1/0) mice displayed a ~30% reduction of interstitial and perivascular fibrosis after TAC when compared to Cul7+/+;Myh6-Mer-Cre-MerTg(1/0) controls 4 weeks after TAC surgery (12.4% vs. 8.7%, p<0.05) (S4 Fig). Here, MYH6 is linked to persistent truncus arteriosus.