However, it should be noted that Kim et al. identified CUL7 in a functional screen for inhibitors of Myc-induced apoptosis, showing that expression of CUL7 prevented both c-Myc and N-Myc mediated apoptosis and promoted the transformation of neuroblastoma SHEP cells in a p53-dependent manner [37]. The gene discussed is CUL7; the disease is neuroblastoma.